The preexcitation syndrome: epidemiological and genetic study
Identifieur interne : 002571 ( Main/Exploration ); précédent : 002570; suivant : 002572The preexcitation syndrome: epidemiological and genetic study
Auteurs : Zijad Durakovi [Croatie] ; Asaf Durakovi [États-Unis] ; Andrija Kastelan [Croatie]Source :
- International Journal of Cardiology [ 0167-5273 ] ; 1991.
Abstract
A sample of 4210 subjects of both sexes aged 35–54 years was examined, chosen at random from six regions of Croatia. An electrocardiogram at rest was performed in all subjects and changes analyzed by the Minnesota code. A short P-R interval together with a widening QRS complex and a delta wave was found in 0.05%, while 42 (1.0%) of the examinees had a short P-R interval, but only 0.21% were symptomatic. Three years after the first examination 0.06% of the subjects had preexcitation with a delta wave, and in one subject it appeared after three years. 0.35% of the subjects had a short P-R interval after three years but only 0.18% were symptomatic and in 22 (0.65%) it had disappeared in three years. After 13 years these subjects did not appear for an examination, and the short P-R interval did not appear in any of other subjects during this period. There were more short P-R intervals: 3.22% in females and 1.96% in males, but 0.33% only were symptomatic. Antigens of the human leukocyte group A (HLA) system were analyzed in 46 patients: the Wolff-Parkinson-White syndrome was found in 35, while 11 had the Lown-Ganong-Levine syndrome. Antigens of the HLA-A, HLA-B and HLA-DR locuses were determined by the microlymphocytotoxicity method. The results of the frequency of HLA system antigens were compared to the results of the control group of a Croatian population consisting of 175 people. There was an increased frequency of HLA-A9 and HLA-B5 (P = 0.026 and 0.0092) in the investigated population as a whole. The participation of HLA-A3 antigen was significantly less among patients (P = 0.03), while HLA-B14 antigen was not found in patients with preexcitation. Within 10 HLA-DR locuses, HLA-DR7 antigen was rather more frequently present, although this was not statistically significant (P = 0.173).
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DOI: 10.1016/0167-5273(92)90175-3
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Duraković, M.D., Dept. of Nuclear Medicine, VA Regional Medical Center, 1601 Kirkwood Hwy, Wilmington, DE 19805</wicri:regionArea><placeName><region type="state">Delaware</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nuclear Medicine, VA Regional Medical Center, Wilmington, Delaware</wicri:regionArea><placeName><region type="state">Delaware</region></placeName></affiliation></author><author><name sortKey="Kastelan, Andrija" sort="Kastelan, Andrija" uniqKey="Kastelan A" first="Andrija" last="Kastelan">Andrija Kastelan</name><affiliation wicri:level="1"><country xml:lang="fr">Croatie</country><wicri:regionArea>Tissue Typing Center, University Hospital, Rebro Medical Faculty University of Zagreb, Croatia</wicri:regionArea><wicri:noRegion>Croatia</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">International Journal of Cardiology</title><title level="j" type="abbrev">IJCA</title><idno type="ISSN">0167-5273</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1991">1991</date><biblScope unit="volume">35</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="181">181</biblScope><biblScope unit="page" to="186">186</biblScope></imprint><idno type="ISSN">0167-5273</idno></series><idno type="istex">CA56BADE79B172C723629FB5B3F294E78A8A5BE3</idno><idno type="DOI">10.1016/0167-5273(92)90175-3</idno><idno type="PII">0167-5273(92)90175-3</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0167-5273</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A sample of 4210 subjects of both sexes aged 35–54 years was examined, chosen at random from six regions of Croatia. An electrocardiogram at rest was performed in all subjects and changes analyzed by the Minnesota code. A short P-R interval together with a widening QRS complex and a delta wave was found in 0.05%, while 42 (1.0%) of the examinees had a short P-R interval, but only 0.21% were symptomatic. Three years after the first examination 0.06% of the subjects had preexcitation with a delta wave, and in one subject it appeared after three years. 0.35% of the subjects had a short P-R interval after three years but only 0.18% were symptomatic and in 22 (0.65%) it had disappeared in three years. After 13 years these subjects did not appear for an examination, and the short P-R interval did not appear in any of other subjects during this period. There were more short P-R intervals: 3.22% in females and 1.96% in males, but 0.33% only were symptomatic. Antigens of the human leukocyte group A (HLA) system were analyzed in 46 patients: the Wolff-Parkinson-White syndrome was found in 35, while 11 had the Lown-Ganong-Levine syndrome. Antigens of the HLA-A, HLA-B and HLA-DR locuses were determined by the microlymphocytotoxicity method. The results of the frequency of HLA system antigens were compared to the results of the control group of a Croatian population consisting of 175 people. There was an increased frequency of HLA-A9 and HLA-B5 (P = 0.026 and 0.0092) in the investigated population as a whole. The participation of HLA-A3 antigen was significantly less among patients (P = 0.03), while HLA-B14 antigen was not found in patients with preexcitation. Within 10 HLA-DR locuses, HLA-DR7 antigen was rather more frequently present, although this was not statistically significant (P = 0.173).</div></front></TEI><affiliations><list><country><li>Croatie</li><li>États-Unis</li></country><region><li>Delaware</li></region></list><tree><country name="Croatie"><noRegion><name sortKey="Durakovi, Zijad" sort="Durakovi, Zijad" uniqKey="Durakovi Z" first="Zijad" last="Durakovi">Zijad Durakovi</name></noRegion><name sortKey="Kastelan, Andrija" sort="Kastelan, Andrija" uniqKey="Kastelan A" first="Andrija" last="Kastelan">Andrija Kastelan</name></country><country name="États-Unis"><region name="Delaware"><name sortKey="Durakovi, Asaf" sort="Durakovi, Asaf" uniqKey="Durakovi A" first="Asaf" last="Durakovi">Asaf Durakovi</name></region><name sortKey="Durakovi, Asaf" sort="Durakovi, Asaf" uniqKey="Durakovi A" first="Asaf" last="Durakovi">Asaf Durakovi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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